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Factores hormonales y genticos Algunas mculas melanticas labiales aparecen durante el embarazo o con el uso de anticonceptivos orales, lo que sugiere un componente hormonal similar al del melasma

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PINK1-Parkin-dependent mitophagy is initiated by mitochondrial membrane depolarization, whereas receptor-mediated mitophagy operates independently of ubiquitin and can be induced by hypoxia or developmental signals